4992Cardiac rotational mechanics in advanced heart failure patients undergoing cardiac assist device implantation predict favorable myocardial functional response
نویسندگان
چکیده
منابع مشابه
Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure.
BACKGROUND Heart failure is associated with impaired myocardial metabolism with a shift from fatty acids to glucose use for ATP generation. We hypothesized that cardiac accumulation of toxic lipid intermediates inhibits insulin signaling in advanced heart failure and that mechanical unloading of the failing myocardium corrects impaired cardiac metabolism. METHODS AND RESULTS We analyzed the m...
متن کاملHeart Failure Ventricular Assist Device Implantation Corrects Myocardial Lipotoxicity, Reverses Insulin Resistance, and Normalizes Cardiac Metabolism in Patients With Advanced Heart Failure
Background—Heart failure is associated with impaired myocardial metabolism with a shift from fatty acids to glucose use for ATP generation. We hypothesized that cardiac accumulation of toxic lipid intermediates inhibits insulin signaling in advanced heart failure and that mechanical unloading of the failing myocardium corrects impaired cardiac metabolism. Methods and Results—We analyzed the myo...
متن کاملSurgical Treatment of Advanced Heart Failure- Left Ventricular Assist Device Implantation and Adjuvant Tricuspid Valve Repair
Cardiac transplantation is the treatment of choice in patients with end-stage heart failure. Insufficient number of donors in all health systems resulted in the need for intensive development of devices for mechanical circulatory support. Right ventricular failure (RVF) combined with major tricuspid insufficiency among the group of patients who are candidates for the left ventricular assist dev...
متن کاملRight heart failure and benefits of adjuvant tricuspid valve repair in patients undergoing left ventricular assist device implantation.
OBJECTIVES Although right heart failure (RVF) is an important issue in the management of patients with left ventricular assist devices (LVADs), the benefits of performing tricuspid valve repair in conjunction with LVAD implantation have not been demonstrated. METHODS We retrospectively reviewed the records of 141 patients who received LVAD implantation as a bridge to transplant from May 1999 ...
متن کاملTo ventricular assist devices or not: When is implantation of a ventricular assist device appropriate in advanced ambulatory heart failure?
Advanced heart failure has been traditionally treated via either heart transplantation, continuous inotropes, consideration for hospice and more recently via left ventricular assist devices (LVAD). Heart transplantation has been limited by organ availability and the futility of other options has thrust LVAD therapy into the mainstream of therapy for end stage heart failure. Improvements in tech...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Heart Journal
سال: 2017
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehx493.4992